野生动物疫病与免疫研究中心

发布时间:2019-08-01

  2018年野生动物疫病与免疫研究中心组建,现有人员14人,其中研究员1名,副研究员1名,助理研究员7名,研究生11名。研究中心以国家和广东省战略需求为导向,旨在聚焦现代农业、保护生物学等领域国际前沿与研究热点,围绕野生动物健康与病原生物学、环境微生物资源开发和生态治理、耐药性微生物与公共卫生健康核心科学问题,开展精准化、系统化的基础应用研究,为广东省野生动物保护、养殖业健康发展、生态环境治理和公共卫生安全服务。


  科研方向

  1.微生物病原生态学

  2.野生动物疫病防控与免疫研究


  科研团队

  一级PI(中心主任): 王承民

  王承民,河北承德人,广东省科学院“引进领军人才”,华南农业大学和河北农业大学硕士生导师。现任广东省科学院动物研究所野生动物疫病与免疫研究中心主任,微生物病原生态学研究组组长。1996-2003年在河北农业大学获得学士和硕士学位,2007-2010年在中国科学院动物研究所获得理学博士学位,2003-2007年在河南科技学院工作,2010-2018年在中国科学院动物研究所工作(2013年美国USDA学术交流),2018年至今在广东省科学院动物研究所工作。近年来,主持或参加科技部十一五、十二五和十三五重点研发计划,国家自然科学基金、中国科学院先导A等项目,在Cell Reports, Journal of Infectious Diseases, Reviews In Medical Virology,Frontiers in Cellular and Infection Microbiology, Frontiers in genetics, Journal of wildlife diseases,科学通报,生物化学与生物物理进展等发表文章72篇,其中SCI论文52篇,累计影响因子147.79,总被引用710率次。申请专利11项(授权4件,包括2件国际专利),编写著作9部,其中英文著作1部,参与制定标准2项。

  二级PI:陈金平

  研究员,博士生导师。现任广东省科学院动物研究所副所长、野生动物疫病与免疫学研究中心副主任,野生动物疫病防控与分子生态学研究组组长。1999年-2002年获得哈尔滨师范大学动物学硕士学位,2002年-2005年获得中国科学院动物研究所生态学博士学位。1997年-2002年,在中国水产科学研究院黑龙江水产研究所工作;2005年-2006年,在中国科学院广州生物医药与健康研究院工作,期间在法国国家自然博物馆从事合作研究;2006年至今在广东省科学院动物研究所工作;2014年-2015年,作为访问学者在美国康奈尔大学兽医学院从事分子疫苗相关研究。近年来主持国家、省、市等各类科研项目15项;获得获广东省科学技术二等奖1项,广东省自然科学二等奖1项;发表学术论文91篇,其中SCI收录 69 篇。申请国家发明专利12件,其中授权8件,申请国际发明专利1件。

    

  研究组:

  1.微生物病原生态学研究组 组长:王承民 副研究员

  微生物病原生态学研究组于2018年9月成立,围绕微生物开展研究工作,主要设置微生物耐药与公共卫生安全、环境微生物与生态治理、噬菌体资源与产业化等三个研究方向,基于微生物生物学特性、微生物基因组学、转录组学等手段,开展了耐药性细菌在野生动物-家养动物-人-环境 生态圈的扩散、环境微生物生物表型和基因组特征等工作,现有人员9人,其中研究生3人,发表SCI文章54篇,申报专利5项,其中国际专利2项。

  2.野生动物疫病防控研究组 组长:陈金平 研究员

  野生动物疫病防控研究组共12人,其中博士7人,硕士2人,本科2人,其他1人,由高级职称2人,博士后3人,助理研究员4人,研究实习员1人,硕士研究生1人,本科实习生1人组成,具有动物学、基因组学、遗传育种学、分子生物学、生物技术等多学科背景,是一支年轻的团队。


  科研成果概况、近五年科研成果列表

  本团队共主持国际、国家、省、市等各类项目20余项,目前在研国家项目2项,省、市项目6项。共发表SCI论文91篇(SCI收录69篇);授权国家发明专利9件,其中8件,PCT专利2件,日本发明专利1件;获广东省科学技术二等奖1项,广东省自然科学二等奖1项。


  学术论文:

  1、Ping Liu#, Jingzhe Jiang#, Xiufeng Wan, Yan Hua, Linmiao Li, Jiabin Zhou, Xiaohu Wang, Fanghui Hou, Jing Chen, Jiejian Zou, Jinping Chen*, Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)?, PLoS Pathog, 2020,16(5): e1008421.

  2、Hafiz Ishfaq Ahmad, Jiabin Zhou , Muhammad Jamil Ahmad , Gulnaz Afzal, Haiying Jiang, Xiujuan Zhang, Abdelmotaleb A. Elokil, Musarrat Abbas Khan, Linmiao Li, Huiming Li, Liu Ping , Jinping Chen*. Adaptive selection in the evolution of programmed cell death-1 and its ligands in vertebrates. Aging, 2020, 12(4):3516-3557.

  3、Hafiz Ishfaq Ahmad, Akhtar Rasool Asif, Muhammad Jamil Ahmad, Farwa Jabbir , Muhammad Adnan, Shakeel Ahmed, Gulnaz Afzal, Ali Haider Saleem , Linmiao Li, Haiying Jiang , Mario Juan Simirgiotis , Mubashar Rauf, Jinping Chen*. Adaptive evolution of peptidoglycan recognition protein family regulates the innate signaling against microbial pathogens in vertebrates. Microbial Pathogenesis, 2020:104361.

  4、Huiming Li , Ping Liu , Xiujuan Zhang , Linmiao Li, Haiying Jiang , HuaYan , Fanghui Hou, Jinping Chen*. Combined proteomics and transcriptomics reveal the genetic basis underlying the diferentiation of skin appendages and immunity in pangolin. Scientific Reports. (2020) 10:14566 | https://doi.org/10.1038/s41598-020-71513-w.

  5、Huiming Li, Bize Yang, Xiujuan Zhang, Haiying Jiang, Linmiao Li, Hafz Ishfaq Ahmad, Jinping Chen*. Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris). Scientific Reports | (2020) 10:13920. https://doi.org/10.1038/s41598-020-70844-y.

  6、Huiming Li, Bize Yang, XueJun Jin, Jinping Chen*, Parentage and Genetic iversity Studies in Pangolin (Manis javanica) Using Novel Microsatellite Markers, Pakistan Journal of Zoology, Pakistan J. Zool., 2020, in press

  7、Jie Zhang* , Jiwei Qi , Fanglei Shi , Huijuan Pan , Meng Liu , Ran Tian , Yuepan Geng, Huaying Li , Yujie Qu , Jinping Chen*, Inge Seim* , Ming Li *, Insights into the evolution of neoteny from the genome of the Asian icefish Protosalanx chinensis, iScience 2020, 23, 101267 doi: https://doi.org/10.1016/j.isci.2020.101267.

  8、Haiying Jiang, Wu Chen, Li Su, Mingwei Huang, Libo Lin, Qiao Su, Guanyu Li, Hafiz Ishfaq Ahmad, Linmiao Li, Xiujuan Zhang, Huiming Li, Jinping Chen*. Impact of host intraspecies genetic variation, diet, and age on bacterial and fungal intestinal microbiota in tigers. MicrobiologyOpen. 2020, 00:e1050.

  9、Guoshuai Tang , Xixi Liang , Mengyuan Yang, Tingting Wang, Jinping Chen, Weiguo Du , Huan Li*, Baojun Sun*. Captivity Influences Gut Microbiota in Crocodile Lizards (Shinisaurus crocodilurus). Front. Microbiol. 11:550. doi: 10.3389/fmicb.2020.00550.

  10、Hafiz I. Ahmad, Fabiana Neves, Muhammad J. Ahmad, Sunny Ahmar, Abdelmotaleb A. Elokil, Jinping Chen*. The domestication makeup: evolution, survival, and challenges. Front. Ecol. Evol. 8:103.doi: 10.3389/fevo.2020.00103.

  11、Xiujuan Zhang, Jiabin Zhou, Linmiao Li, Wenzhong Huang, Hafiz Ishfaq Ahmad, Huiming Li, Haiying Jiang, Jinping Chen*. Full-length transcriptome sequencing and comparative transcriptomic analysis to uncover genes involved in early gametogenesis in the gonads of Amur sturgeon (Acipenser schrenckii). Zhang et al. Frontiers in Zoology (2020) 17:11 https://doi.org/10.1186/s12983-020-00355-z.

  12、Ping Liu, Wu Chen, Jinping Chen*, Viral Metagenomics Revealed Sendai Virus and Coronavirus infection of Malayan Pangolins (Manis javanica), Viruses, 2019, 11, 979.

  13、Juan Li, Haiying Jiang, Linmiao Li, Xiujuan Zhang, Jinping Chen*. The effect of       disease and season to hepatopancreas and intestinal mycobiota of Litopenaeus vannamei, Frontiers in Microbiology, 2019, 10:889. 

  14、Haiying Jiang, Xiujuan Zhang, Linmiao Li, Jinge Ma, Nan He, Haiyang Liu, Richou Han, Huiming Li, Zhengjun Wu, Jinping Chen*. Identification of Austwickia chelonae as cause of cutaneous granuloma in endangered crocodile lizards using metataxonomics, Peer J, 2019, 7: e6574.

  15、Lihong Yuan, Linmiao Li, Xiujuan Zhang, Haiying Jiang, Jinping Chen*.        Identification and differential expression of piRNAs in the gonads of Amur sturgeon (Acipenser schrenckii), Peer J, 2019, 7: e6709. 

  16、Xiujuan Zhang, Guanyu Li, Haiying Jiang, Linmiao Li, Jine Ma, Huiming Li, Jinping Chen*. Full-length transcriptome analysis of Litopenaeus vannamei reveals transcript variants involved in the innate immune system. Fish and shellfish immunology, 2019, 87: 346-359.

  17、Jinge Ma, Haiying Jiang, Linmiao Li, Xiujuan Zhang, Huiming Li, Guanyu Li; Daying Mo, Jinping Chen*. SMRT sequencing of the full-length transcriptome of the Sunda pangolin (Manis javanica), gene, 2019, 692:208-216. 

  18、Xiahu Wang, Wu Chen, Rong Xiang , Linmiao Li, Jing Chen, Zhong RQ, Hua Xiang,  JinPing Chen *.Complete Genome Sequence of Parainfluenza Virus 5 (PIV5) from a Sunda Pangolin (Manis javanica) in China. Journal of Wildlife Disease,2019,55(4). DOI: 10.7589/2018-09-211.

  19、Liang Zhang, Haiying Jiang, Linmiao Li*, Jinping Chen. Complete mitochondrial genome of Opisthotropis andersonii (Serpentes: Colubridae) determined using next-generation sequencing. Mitochondrial DNA Part B-Resources,2019,4:1, 1012-1013.

  20、Jinge Ma, Haiying Jiang,Linmiao Li, Xiujuan Zhang,Guanyu Li, Huiming Li, Xuejun Jin, JinPing Chen *. The fecal metagenomics of Malayan pangolin identifies an extensive adaptation to myrmecophagy.Frontiers in microbiology, 2018, 9:2793.

  21、Haiying Jiang, Mingwei Huang, Libo Lin, Nan He, Jinping Chen*. Complete genome sequence of Austwickia chelonae LK16-18, isolated from crocodile lizards. Microbiology Resource Announcements, 2018, 7: e01140-18.

  22、Haiying Jiang, Libo Lin, Mingwei Huang, Yingan Zang, Jinping Chen*. Genome Sequence of Morganella morganii DG56-16, Isolated from Shinisaurus crocodilurus.2019, 8(4), e01301-18.

  23、Xiujuan Zhang, Jinge Ma, Linmiao Li, Haiying Jiang, Jinping Chen*. Effects of Different Cytoprotectants Combination on Sperm Survival, Fertility and Embryo Development in Amur Sturgeon (Acipenser schrenckii). Animal and Veterinary Sciences,2018; 6(4): 51-57

  24、Jinge Ma, Linmiao Li, Haiying Jiang, Xiujuan Zhang, Juan Li, Guanyu Li, Jinping Chen*. Acidic mammalian chitinase gene is highly expressed in the special oxyntic glands of Manis javanica, FEBS Open Bio,2018, 8(8):1247-1255.

  25、Juan Li, Linmiao Li, Haiying Jiang, Lihong Yuan, Libiao  Zhang, Jing?e Ma,  Xiujuan Zhang, Minhua Cheng, Jinping Chen*, Fecal Bacteriome and Mycobiome in Bats with Diverse Diets in South China, Current Microbiology, 2018, 75:1352–1361.

  26、Xiujuan Zhang, Linmiao Li, Haiying Jiang, Jing E. Ma, Juan Li, Jinping Chen*,Identification and differential expression of microRNAs in testis and ovary of Amur sturgeon (Acipenser schrenckii), Gene, 2018,658, 36-46.

  27、Haiying Jiang, Jinge Ma ,Juan Li, Xiujuan Zhang,  Linmiao Li , Nan He, Haiyang Liu , Shuyi Luo, Zhenjun Wu, Richou Han, Jinping Chen*,Diets alter the gut microbiome of Crocodile Lizards,Frontiers in Microbiology,2017, 8: 2073.

  28、Linmiao Li, Li Wei, Jinge Ma, Jinping Chen *,Development and characterization of 21 SNP markers in Manis javanica based on high-throughput sequencing,Conservation Genetics Resources,2018,10(3), 351-353.

  29、Jinge Ma,  Linmiao Li, Haiying Jiang, Xiujuan Zhang, Jun Li, Guanyu Li ,  Lihong Yuan, Jun Wu, Jinping Chen*,Transcriptomic analysis identifies genes and pathways related to myrmecophagy in the Malayan pangolin (Manis javanica),Peer J,2017,5:e4140.

  30、Haiying Jiang, Juan Li, Linmiao Li, Xiujuan Zhang, Lihong Yuan, Jinping Chen*. Selective evolution of Toll-like receptors 3, 7, 8, and 9 in bats. Immunogenetics, 2017, 69:271-285. 

  31、Xiujuan Zhang, Lihong Yuan, Linmiao Li, Haiying Jiang, Jinping Chen*. Conservation, sex-biased expression and functional annotation of microRNAs in the gonad of Amur sturgeon (Acipenser schrenckii). Comparative Biochemistry and Physiology, Part D, 2016, 18: 54–61.

  32、Le Han, Weijun He, Huixin Yan, Xianglan Li, Chengmin Wang,Qiumei Shi, Tiezhong Zhou,Guoying Dong. The evolution and molecular characteristics of H9N2 avian influenza viruses in Jiangxi of China. Journal of Medical Virology, 2019, 91:711-716.(IF= 2.049,期刊排名:116 / 272, Medicine, 2区.第5作者)

  33、Guoyao Ma, Lin Chen, Jing Luo, Bo Wang, Chengmin Wang, Meng, Chengmei Huang, Juan Du, Jiajun Ma, Yungfu Chang and Hongxuan He. Histone acetyl transferase TIP60 inhibits the replication of influenza a virus by activation the TBK1-IRF3 pathway. Virology Journal, 2018,15:172( IF= 2.464,期刊排名:91 / 272, Medicine, 2区.第5作者)

  34、Meng Li,Lin Zhao,Jiajun Ma,Na Zhao,Jing Luo,Chengmin Wang,Lin Chen, Guoyao Ma,Yutian Wang,Hongxuan He. Vibrio vulnificus in aquariums is a novel threat to marine mammals and public health. Transbound Emerg Dis. 2018, 65:1863–1871. ( IF= 3.554,期刊排名:2 / 165, Veterinary, 1区.第6作者)

  35、Chengmin Wang, Lyu N, Deng L, Wang J, Gu W, Ding H, Wu Y, Luo J, Wang L,Lyv X, Liu X, Tao Y and He H. Evolutionary Pattern and Large-Scale Architecture of Mutation Networks of 2009 A (H1N1) Influenza A Virus. Front. Genet. 2018, 9:204. (IF=4.151,期刊排名:31/176, Genetics & Heredity,1区,第1作者)

  36、Chengmin Wang, pengpeng liu, Jing Luo, Hua Ding, yan gao, Lei Sun, fubing luo, xiaodong liu and Hongxuan He. Geldanamycin reduces acute respiratory distress syndrome and promotes the survival for of mice infected with the highly virulent H5N1 influenza virus. Front. Cell. Infect. Microbiol.2017, 7:267.IF=5.218,期刊排名:25/124, Microbiology,1区,第1作者

  37、Chengmin Wang , Huimin Liu, Jing Luo, Lin Chen, Meng Li, Wen Su, Na Zhao , Shelan Liu , Li Xie , Yaxiong Jia , Hua Ding , Xiufeng Wan , Hongxuan He. HA Triggers the Switch from MEK1 SUMOylation to Phosphorylation of the ERK Pathway in Influenza A Virus-Infected Cells and Facilitates Its Infection. Front. Cell. Infect. Microbiol. 2017,7:27. (IF=5.218,期刊排名:25/124, Microbiology,1区,第1作者)

  38、Chengmin Wang, Yanyu Zhang, Jing Luo, Hua Ding, Shelan Liu, Said Amer, Li Xie,Wenting Lyv, Wen Su, Meng Li, Qinmiao Sun, Jiayin Dai & Hongxuan He.Identification of miRNomes reveals ssc-miR-30d-R_1 as a potential therapeutic target for PRRS viral infection. Scientific reports.2016 ,6:24854. (IF=5.228,期刊排名:7/62, Multidisciplinary Sciences.1区.第1作者)

  39、Chengmin Wang, Jing Luo, Haijing Wang, Said Amer, Hua DING, Ying Dong, and Hongxuan He. Isolation and characterization of a Neisseria.sp from the captive wild goose (Anser anser).Integr Zool. 2016,11(2):128-33.(IF=1.722,期刊排名:38/161, Zoology,1区,第1作者)

  40、Chengmin Wang, Jing Wang, Wen Su, Shanshan Gao, Jing Luo, Min Zhang, Li Xie, Shelan Liu, Xiaodong Liu, Yu Chen, Yaxiong Jia, Hong Zhang, Hua Ding, Hongxuan He. Relationship between domestic and wild birds in live poultry market and a novel human H7N9 virus in China. J Infect Dis. 2014,209(1):34-7. (IF=5.778,期刊排名:5/72,Infectious Diseases,1区,第1作者)

  41、Chengmin Wang, Yanyu Zhang, Bin Wu, Shelan Liu, Ping Xu, Yanmin Lu, Jing Luo, Dale Louis Nolte, Thomas Jude Deliberto, Mingxing Duan, Hong Zhang, Hongxuan He.Evolutionary Characterization of the Pandemic H1N1/2009 Influenza Virus in Humans Based on Non-Structural Genes. PLoS ONE. 2013;8(2):e56201.(IF=3.73,期刊排名:7/56,Multidisciplinary Sciences,1区,第1作者)

  42、Chengmin Wang, Jing Luo, Said Amer, Yunhai Guo, Yi Hu, Yanmin Lu, Haijing Wang, Mingxing Duan, Hongxuan He.Multivalent DNA vaccine induces protective immune responses and enhanced resistance against Cryptosporidium parvum infection. Vaccine. 2011,29, 323–328. (IF=3.572,期刊排名:25/106, Medicine, Research & Experimental,1区,第1作者)

  43、Chengmin Wang, Yanyun Wu, Jianhua Qin, Haoxue Sun, Hongxuan He. Induced Susceptibility of Host Is Associated with an Impaired Antioxidant System Following Infection with Cryptosporidium parvum in Se-Deficient Mice. PLoS ONE. 2009,4(2): e4628.(.IF=4.351,期刊排名:10/76, Biology,1区,第1作者)

  44、Lin Chen, Chengmin Wang, Jing Luo, Wen Su, Meng Li, Na Zhao, Wenting Lyu , Attaran H, Yapeng He, Hua Ding and Hongxuan He. Histone Deacetylase 1 Plays an Acetylation- Independent Role in Influenza A Virus Replication.Front. Immunol.2017, 8:1757 (IF=6.429,期刊排名:21/151,Immunology,1区,第1作者(共同))

  45、Shelan Liu, Chengliang Chai, Chengmin Wang, Said Amer,Huakun Lv, Hongxuan He, Jimin Sun and Junfen Lin.Systematic review of severe fever with thrombocytopenia syndrome: virology, epidemiology, and clinical characteristics. Reviews in Medical Virology. 2014,24: 90–102 (IF=5.759,期刊排名:5/33,Virology,1区,第1作者(共同))

  46、Bin Wu, Chengmin Wang, Guoying Dong, Yunhai Guo, Dale Louis Nolte, Thomas Jude Deliberto, Jianguo Xu,Mingxing Duan, Hongxuan He.New Evidence Suggests Southern China as a Common Source of Multiple Clusters of Highly Pathogenic H5N1 Avian Influenza Virus. Journal of Infectious diseases. 2010,202:452–458(IF=6.228,期刊排名:5/58,Infectious Diseases,1区,第1作者(共同))

  47、Chengmin Wang, Jing Luo,Jing Wang,Wen Su, Shanshan Gao, Min Zhang, Li Xie,Hua Ding,Shelan Liu,Xiaodong Liu,Yu Chen,Yaxiong Jia,Hongxuan He. Novel human H7N9 influenza virus in China. Integrative Zoology.2014,9: 372–375 (IF=1.419,期刊排名:47/153, Zoology,2区,第1作者)

  48、Chengmin Wang,Hongxuan He Leptospira spp. In Commensal Rodents, Beijing, China. J Wildl Dis. 2013,49(2):461-3. (IF=1.271,期刊排名:48/143, Veterinary Sciences,2区,第1作者)


  授权发明专利:

  1.陈金平,李林妙,覃茂林,刘灯红. 国家发明专利:一种施氏鲟雌鱼和匙吻鲟雄鱼杂交育苗方法. 专利号:ZL201710698134.9;授权公告日:2020.1.7.

  2.张秀娟、陈金平、吴文化、周佳滨、李林妙. 国家发明专利:江海英鉴定鲟鱼性别的microRNA血清标志物、引物组、试剂盒及其应用. 专利号:ZL202010314533.2;授权公告日:2020.7.24.

  3.张秀娟、陈金平、白银山、张守全、王承民. 国家发明专利:一种利用FACT Ⅲ微载体体外扩增精原干细胞的三维动态培养方法. 专利号:ZL202010314524.3;授权公告日:2020.7.31.

  4.原丽红,李林妙.日本专利:一条D螺旋区突变的瘦素活性肽及其编码基因和应用.专利号:特许第6486482号;授权公告日:2019.3.1.

  5.原丽红,李林妙.日本专利:一条D螺旋区突变的瘦素活性肽及其编码基因和应用.专利号:ZL201510228121.6;授权公告日:2017.11.28.

  6.原丽红,陈金平. 国家发明专利:一条 CD 环和 E 螺旋区突变的瘦素活性肽及其编码基因和应用.专利号:ZL201510228093.8;授权公告日:2017.11.06.

  7.原丽红,张树义,陈金平,林本夫,左学国,何灵江. 国家发明专利:棕果蝠瘦素蛋白及其cDNA序列. 专利号:ZL200910039440.7; 授权公告日:2011.08.24.

  8.原丽红,张树义,林本夫,何灵江,左学国,陈金平. 国家发明专利:马铁菊头蝠瘦素蛋白及其cDNA序列. 专利号:ZL200910039438.X, 授权公告日:2011.09.28.

  9. 原丽红,张树义,林本夫,左学国,何灵江,陈金平. 国家发明专利:长翼蝠瘦素蛋白及其cDNA序列, 专利号:ZL200910039439.4, 授权公告日:2011.08.24.

  10. 吴文化,孙大江,张颖,宋聃,陈金平,王念民. 国家发明专利:一种达氏鳇苗种的低温驯化培育方法, 专利号:ZL201310533824.0, 授权公告日:2016.03.23.

  11. 原丽红,陈金平,一条CD环和E螺旋区突变的瘦素活性肽及其编码基因和应用,PCT专利(PCT/CN2015/088554),优先权日2015.5.7,已申请进入日本,日本申请号:2017-540624。


  科技奖项

  1、2018年,“我国鲟鱼资源评价、性腺发育研究及应用”获2017年度广东省科技进步二等奖。

  2、2019年,“蝙蝠特殊生存策略的机理研究”获2018年度广东省自然科学奖二等奖

   

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获奖照片

  

    

  

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